In the United States, one out of three adults is overweight (30.7%), and more than two in five adults (42.4%) are obese. For those who have not found success with lifestyle changes alone, the introduction of prescription pills or injectable therapies has brought a new ray of hope. Regulated by the FDA and backed by scientific research, these medications provide much-needed support for individuals facing genetic and medical barriers to weight loss, offering a glimmer of hope in their weight loss journey. This comprehensive guide explores the most common types of weight-loss medicines, how they work, and tips before starting them.
Types of weight loss medications
There is a range of medically approved weight loss products and options available, such as injectables and drugs. These include oral prescription pills and injectable medications. Each class of medication works differently; some impact digestion, some suppress appetite, and some focus on regulating hormones. Weight loss drugs are developed to treat weight loss when complemented with lifestyle changes. They are typically prescribed for people with a BMI of 30 or higher or those with a BMI of 27 or higher and related health conditions.
Prescription weight loss pills
Prescription weight loss pills are the most common starting point for weight loss journeys. They are easy to use and provide convenience, but their effectiveness depends on individual health profiles and correct usage. Here are the most common prescription pills.
- Phentermine- Phentermine is a stimulant that suppresses appetite, and is recommended for short-term use only for up to 12 weeks. Patients may experience side effects when taking these pills, such as insomnia and/or an increased heart rate.
- Orlistat (Xenical/Alli): These are non-stimulant options that inhibit fat absorption in the intestine. Side effects include flatulence and oily stools.
- Phentermine/Topiramate (Qsymia): This is a combination medication that enhances metabolism and suppresses appetite. It requires a prescription and is not suitable for pregnant women.
- Naltrexone/ Bupropion: This medication affects the patient’s hunger and the brain’s reward system. It helps reduce emotional or habitual eating.
Weight loss medication injection (GLP-1 Receptor Agonists)
The injectable medication has gained popularity worldwide due to its effectiveness and hormonal mechanism of action. These drugs replicate GLP-1 (glucagon-like peptide-1), a natural hormone that helps reduce appetite, regulate blood sugar levels, and slow gastric emptying. The following are the GLP-1-based injections.
- Semaglutide – it is used once a week, and a clinical trial represents up to 15% of total body fat loss. It also improves cardiovascular risk markers and insulin sensitivity.
- Liraglutide – These are daily injections that result in slower weight loss than semaglutide, but are still effective. Initially developed for the treatment of diabetes, the use of liraglutide has expanded over the years.
Both injections have the potential to aid in weight loss, which can help reduce cravings and improve portion control. It is also beneficial in managing type 2 diabetes.
The injections also have side effects, like vomiting, nausea, and diarrhea. At the same time, it requires regular medical monitoring.
What is the strongest weight loss prescription pill?
The most effective medication varies based on diverse factors such as metabolic conditions, Body Mass index, risk factors, health status, and response to treatment. Choosing the “strongest medication” is a highly individualized decision, and several key considerations should be taken into account. This individualized approach empowers you to make the best decision for your weight loss journey.
- Phentermine – provides positive results in terms of appetite suppression, but it is not approved for long-term use.
- Semaglutide yields the highest average weight loss results, up to 15%.
- Combination medications, such as Qsymia, can provide enhanced results for specific individuals.
- Always consult with your doctor before starting any weight loss medication. Your doctor can help you understand the potential risks and benefits, and they can also monitor your progress and adjust your treatment plan as needed.
Weight loss pills that actually work
Amidst the flood of unregulated and ineffective products in the weight loss market, it is essential to focus on medications with clinically proven results. FDA-approved medications stand out as more effective than others, producing measurable results, primarily when used in conjunction with lifestyle changes or improvements. This assurance can instill confidence in your weight loss journey, knowing that you are on the right path with FDA-approved medications.
Evidence-based medication and outcomes
- Phentermine-topiramate (Qsymia): In the CONQUER trial, patients lost an average of 10% of their body weight over 56 weeks, which is equivalent to approximately 10% of their body fat. 70% of the participants reported achieving a weight loss of at least 5%.
- Semaglutide (Wegovy) : The STEP-1 clinical trial reflected an average weight loss of 14.9% over 56 weeks. Eighty-six percent of participants reported a 5% weight loss and marked improvement in blood pressure, waist circumference, and glucose control.
- Liraglutide (Saxenda) : In the SCALE trial, patients experienced an 8% reduction in body fat after 1 year. Sixty-three percent of participants reported achieving a minimum weight loss of 5%. It is effective for delaying the onset of type 2 diabetes in prediabetic patients.
- Orlistat (Xenical/Alli): Clinical trials have demonstrated that a 3% to 5% additional weight loss is achieved when lifestyle intervention is combined with the medication.
Considerations before starting medication
Before embarking on any weight loss medication, it’s essential to undergo a comprehensive medical evaluation. This evaluation, conducted by a qualified healthcare professional, will consider factors such as medication interactions, health risks, and lifestyle factors to ensure that the chosen medication is safe and effective.
- Medical history: certain conditions, such as uncontrolled high blood pressure, heart disease, or a history of eating disorder, may contribute to which specific weight loss medications your doctor will prescribe you.
- Weight-loss criteria: These medications are typically prescribed for individuals with a body mass index (BMI) of 30 or higher. Understanding this eligibility criterion can help you determine if these medications are a suitable option for your weight loss journey.
- Potential side effects: the common side effects include constipation, nausea, and diarrhea. For a detailed assessment, consult with an Advanced Internal Medicine specialist.
Long-term use and weight maintenance- Discontinuing the medication can lead to weight regain if the lifestyle changes are not maintained with adequate care. - Lifestyle commitment: Medications are more effective when combined with regular exercise and a healthy diet.
The importance of lifestyle change
Prescription of weight loss medication can support your weight-loss journey, but it is not a perfect substitute for healthy habits. Long-term, sustainable results are achieved when medications are combined with behavioral changes, a nutritious diet, and regular physical activity.
A core focus must be made on diet with a focus towards portion control, whole foods, and reduced sugar intake. Utilize tools such as therapy and mindfulness to manage stress effectively.
Conclusion
Weight loss medication can play a significant role in helping individuals maintain and achieve their healthy weight. These medications are most effective when used under strict medical supervision and in conjunction with lifestyle modifications. Whether you are just starting or need expert consultation, Advanced Internal Medicine can offer a streamlined approach for long-term success. Before starting medication, it is recommended to consult with the healthcare provider and choose a solution tailored to your lifestyle and medical needs. The Advanced Internal Medicine team is here to support and guide you in your weight management journey.
Curious About Weight Loss Medications?
Find out whether medication could be right for you. Our providers will explain your options and monitor your progress.
FAQ
Q. What medications are FDA-approved for weight loss?
Ans: A wide range of FDA-approved medications is available, including semaglutide (Wegovy), phentermine-topiramate, orlistat (Xenical), and liraglutide (Saxenda). These medications work by increasing fullness, reducing appetite, or blocking fat absorption.
Q. How does Advanced Internal Medicine customize a weight loss program?
Ans: The clinic offers personalized programs tailored to your medical history, long-term goals, and lifestyle. These programs are combined with nutritional counselling and regular monitoring.
Q. Who qualifies for a weight loss program?
Ans: Adults with a Body Mass Index (BMI) of ≥30, or ≥27 with conditions such as hypertension or diabetes. Our specialist provider will assess your eligibility.
Q. Are there any side effects associated with the weight loss program?
Ans: Yes, the side effects may vary by medication but may include dry mouth, insomnia, nausea, vomiting, and gastrointestinal issues.
Q. Does Advanced Internal Medicine accept insurance for the weight loss program?
Ans: Advanced Internal Medicine accepts commercial insurance plans and many Medicaid plans. It is recommended that you contact the clinic to verify coverage for different programs.
Medically Reviewed By
At Advanced Internal Medicine of Northern Illinois, Dr. Ashima Salwan, MD, treats adult and geriatric patients, men and women alike, working through some of the most common and most connected health problems out there: obesity,...
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